Type 2 diabetes mellitus and risk of ovarian cancer in Loja 2000-2017: a case-control study

Abstract

Introduction: ovarian cancer is one of the first deadly malignant neoplasms afflict women. Factors such as type 2 diabetes (T2D) or obesity have been associated with the risk of having ovarian cancer; however, research correlating metabolic problems with ovarian cancer risk is lacking. Objective: Evaluate the risk association between T2D and ovarian cancer.

Methodology: study of cases and controls ratio 1:1. The participants with histopathological diagnosis of ovarian cancer were the eligible cases, and the controls were chosen by a convenience sample of the initial base of patients who underwent a gynecological echo at a tertiary hospital. The exposure of interest was type 2 diabetes mellitus. ORs were calculated using logistic regression.

Results: a total of 270 participants were evaluated (135 per arm). In the group of women with DM2, an OR of 6.1 (95% CI 2.47-15.32) was observed as a risk factor for ovarian cancer. In the multivariate analysis adjusted for confounding factors, obesity (OR 2.6; 95% CI 1.15-6.16) and DM2 (OR 4.9; 95% CI 1.89 - 12.79) remained as independent risk factors for ovarian cancer.

Conclusions: in our study, DM2 behaves as a risk factor for ovarian cancer.

Keywords

Type 2 diabetes, Ovarian cancer, Obesity

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