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Diabetes gestacional. Una revisión sistemática

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Resumen

Introducción: la diabetes gestacional, enfermedad frecuente en el embarazo, cuya prevalencia aumenta en uno de cada seis nacidos vivos en todo el mundo. 

Materiales y métodos: se elaboró una revisión sistemática con la declaración PRISMA 2020.

Resultados: metformina fue superior a la insulina en eventos hipoglucémicos.  La  eficacia, seguridad de la metformina sola o como terapia complementaria a la insulina en el embarazo con diabetes mellitus gestacional con diabetes mellitus tipo 2 redujo el aumento de peso materno , hipoglucemia materna , hipoglucemia neonatal, ingreso a la unidad de cuidados intensivos neonatales y reducción del peso al nacer ≥4000 g.

Conclusiones: la diabetes gestacional se   relaciona con morbilidad perinatal, un mayor riesgo de diabetes y enfermedades cardiovasculares en la madre a futuro y predisposición a obesidad infantil en la descendencia. La metformina reduce el riesgo de ciertos resultados maternos y neonatales en comparación con la terapia con insulina.

Palabras clave

Diabetes, Gestacional, Complicaciones de la diabetes, Diabetes tipo I, Diabetes mellitus tipo II


Citas

  1. Saravanan P; Diabetes in Pregnancy Working Group; Maternal Medicine Clinical Study Group; Royal College of Obstetricians and Gynaecologists, UK. Gestational diabetes: opportunities for improving maternal and child health. Lancet Diabetes Endocrinol. 2020 Sep;8(9):793-800. doi: 10.1016/S2213-8587(20)30161-3.
  2. Malaza N, Masete M, Adam S, Dias S, Nyawo T, Pheiffer C. A Systematic Review to Compare Adverse Pregnancy Outcomes in Women with Pregestational Diabetes and Gestational Diabetes. Int J Environ Res Public Health. 2022 Aug 31;19(17):10846. doi: 10.3390/ijerph191710846. PMID: 36078559; PMCID: PMC9517767.
  3. Wang H, Li N, Chivese T, Werfalli M, Sun H, Yuen L, Hoegfeldt CA, Elise Powe C, Immanuel J, Karuranga S, Divakar H, Levitt N, Li C, Simmons D, Yang X; IDF Diabetes Atlas Committee Hyperglycaemia in Pregnancy Special Interest Group. IDF Diabetes Atlas: Estimation of Global and Regional Gestational Diabetes Mellitus Prevalence for 2021 by International Association of Diabetes in Pregnancy Study Group's Criteria. Diabetes Res Clin Pract. 2022 Jan;183:109050. doi: 10.1016/j.diabres.2021.109050.
  4. Simmons D, Immanuel J, Hague WM, Teede H, Nolan CJ, Peek MJ, Flack JR, McLean M, Wong V, Hibbert E, Kautzky-Willer A, Harreiter J, Backman H, Gianatti E, Sweeting A, Mohan V, Enticott J, Cheung NW; TOBOGM Research Group. Treatment of Gestational Diabetes Mellitus Diagnosed Early in Pregnancy. N Engl J Med. 2023 Jun 8;388(23):2132-2144. doi: 10.1056/NEJMoa2214956. Epub 2023 May 5. PMID: 37144983.
  5. Ye W, Luo C, Huang J, Li C, Liu Z, Liu F. Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis. BMJ. 2022 May 25;377:e067946. doi: 10.1136/bmj-2021-067946.
  6. Simmons D, Immanuel J, Hague WM, Teede H, Nolan CJ, Peek MJ, Flack JR, McLean M, Wong V, Hibbert E, Kautzky-Willer A, Harreiter J, Backman H, Gianatti E, Sweeting A, Mohan V, Enticott J, Cheung NW; TOBOGM Research Group. Treatment of Gestational Diabetes Mellitus Diagnosed Early in Pregnancy. N Engl J Med. 2023 Jun 8;388(23):2132-2144. doi: 10.1056/NEJMoa2214956.
  7. Krejčí H, Šimják P, Anderlová K, Benáková H, Pařízek A, Krejčí V, Škrha J. The incidence of gestational diabetes mellitus before and after the introduction of HAPO diagnostic criteria. Ceska Gynekol. 2019 Winter;84(6):404-411.
  8. Huhn EA, Göbl CS, Fischer T, Todesco Bernasconi M, Kreft M, Kunze M, Vogt DR, Dölzlmüller E, Jaksch-Bogensperger H, Heldstab S, Eppel W, Husslein P, Ochsenbein Kölble N, Richter A, Bäz E, Winzeler B, Hoesli I. Sensitivity, specificity, and diagnostic accuracy of WHO 2013 criteria for diagnosis of gestational diabetes mellitus in low risk early pregnancies: international, prospective, multicentre cohort study. BMJ Med. 2023 Sep 13;2(1):e000330. doi: 10.1136/bmjmed-2022-000330.
  9. Musa E, Salazar-Petres E, Arowolo A, Levitt N, Matjila M, Sferruzzi-Perri AN. Obesity and gestational diabetes independently and collectively induce specific effects on placental structure, inflammation and endocrine function in a cohort of South African women. J Physiol. 2023 Apr;601(7):1287-1306. doi: 10.1113/JP284139.
  10. Huang X, Li Y, Tong X, Wu Y, Zhang R, Sheng L, Xu J, Yu Z, Chen Z, Sun T, Wang F, Yang Q, Li Z, Gao C, Ma L, Ding H, Zang S, Yang N, Zhang TN, Liu J. Increased Circulating IL-32 Is Associated With Placenta Macrophage-derived IL-32 and Gestational Diabetes Mellitus. J Clin Endocrinol Metab. 2024 Jan 18;109(2):333-343. doi: 10.1210/clinem/dgad531.
  11. Xu P, Dong S, Wu L, Bai Y, Bi X, Li Y, Shu C. Maternal and Placental DNA Methylation Changes Associated with the Pathogenesis of Gestational Diabetes Mellitus. Nutrients. 2022 Dec 23;15(1):70. doi: 10.3390/nu15010070.
  12. Page L, Younge N, Freemark M. Hormonal Determinants of Growth and Weight Gain in the Human Fetus and Preterm Infant. Nutrients. 2023 Sep 18;15(18):4041. doi: 10.3390/nu15184041.
  13. Balachandiran M, Bobby Z, Dorairajan G, Gladwin V, Vinayagam V, Packirisamy RM. Decreased maternal serum adiponectin and increased insulin-like growth factor-1 levels along with increased placental glucose transporter-1 expression in gestational diabetes mellitus: Possible role in fetal overgrowth. Placenta. 2021 Jan 15;104:71-80. doi: 10.1016/j.placenta.2020.11.008.
  14. Marson EJ, Kamarajah SK, Dyson JK, White SA. Pregnancy outcomes in women with liver transplants: systematic review and meta-analysis. HPB (Oxford). 2020 Aug;22(8):1102-1111. doi: 10.1016/j.hpb.2020.05.001.
  15. Hillier TA, Pedula KL, Ogasawara KK, Vesco KK, Oshiro CES, Lubarsky SL, Van Marter J. A Pragmatic, Randomized Clinical Trial of Gestational Diabetes Screening. N Engl J Med. 2021 Mar 11;384(10):895-904. doi: 10.1056/NEJMoa2026028.
  16. Li YX, Long DL, Liu J, Qiu D, Wang J, Cheng X, Yang X, Li RM, Wang G. Gestational diabetes mellitus in women increased the risk of neonatal infection via inflammation and autophagy in the placenta. Medicine (Baltimore). 2020 Oct 2;99(40):e22152. doi: 10.1097/MD.0000000000022152.
  17. Dłuski DF, Ruszała M, Rudziński G, Pożarowska K, Brzuszkiewicz K, Leszczyńska-Gorzelak B. Evolution of Gestational Diabetes Mellitus across Continents in 21st Century. Int J Environ Res Public Health. 2022 Nov 28;19(23):15804. doi: 10.3390/ijerph192315804.
  18. Ni W, Gao X, Su X, Cai J, Zhang S, Zheng L, Liu J, Feng Y, Chen S, Ma J, Cao W, Zeng F. Birth spacing and risk of adverse pregnancy and birth outcomes: A systematic review and dose-response meta-analysis. Acta Obstet Gynecol Scand. 2023 Dec;102(12):1618-1633. doi: 10.1111/aogs.14648.
  19. Francis EC, Powe CE, Lowe WL Jr, White SL, Scholtens DM, Yang J, Zhu Y, Zhang C, Hivert MF, Kwak SH, Sweeting A; ADA/EASD PMDI. Refining the diagnosis of gestational diabetes mellitus: a systematic review and meta-analysis. Commun Med (Lond). 2023 Dec 18;3(1):185. doi: 10.1038/s43856-023-00393-8.
  20. Antar SA, Ashour NA, Sharaky M, Khattab M, Ashour NA, Zaid RT, Roh EJ, Elkamhawy A, Al-Karmalawy AA. Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments. Biomed Pharmacother. 2023 Dec;168:115734. doi: 10.1016/j.biopha.2023.115734.
  21. Harper LM, Jauk V, Longo S, Biggio JR, Szychowski JM, Tita AT. Early gestational diabetes screening in obese women: a randomized controlled trial. Am J Obstet Gynecol. 2020 May;222(5):495.e1-495.e8. doi: 10.1016/j.ajog.2019.12.021.
  22. Wu R, Zhang Q, Li Z. A meta-analysis of metformin and insulin on maternal outcome and neonatal outcome in patients with gestational diabetes mellitus. J Matern Fetal Neonatal Med. 2024 Dec;37(1):2295809. doi: 10.1080/14767058.2023.2295809.
  23. Picón-César MJ, Molina-Vega M, Suárez-Arana M, González-Mesa E, Sola-Moyano AP, Roldan-López R, Romero-Narbona F, Olveira G, Tinahones FJ, González-Romero S. Metformin for gestational diabetes study: metformin vs insulin in gestational diabetes: glycemic control and obstetrical and perinatal outcomes: randomized prospective trial. Am J Obstet Gynecol. 2021 Nov;225(5):517.e1-517.e17. doi: 10.1016/j.ajog.2021.04.229.
  24. Dunne F, Newman C, Alvarez-Iglesias A, Ferguson J, Smyth A, Browne M, O'Shea P, Devane D, Gillespie P, Bogdanet D, Kgosidialwa O, Egan A, Finn Y, Gaffney G, Khattak A, O'Keeffe D, Liew A, O'Donnell M. Early Metformin in Gestational Diabetes: A Randomized Clinical Trial. JAMA. 2023 Oct 24;330(16):1547-1556. doi: 10.1001/jama.2023.19869.
  25. He K, Guo Q, Ge J, Li J, Li C, Jing Z. The efficacy and safety of metformin alone or as an add-on therapy to insulin in pregnancy with GDM or T2DM: A systematic review and meta-analysis of 21 randomized controlled trials. J Clin Pharm Ther. 2022 Feb;47(2):168-177. doi: 10.1111/jcpt.13503
  26. Crowley MT, Goulden E, Sanchez-Lechuga B, Fleming A, Kennelly M, McDonnell C, Byrne MM. Case report: Glycaemic management and pregnancy outcomes in a woman with an insulin receptor mutation, p.Met1180Lys. Clin Diabetes Endocrinol. 2024 Mar 10;10(1):5. doi: 10.1186/s40842-024-00166-9.
  27. Antar SA, Ashour NA, Sharaky M, Khattab M, Ashour NA, Zaid RT, Roh EJ, Elkamhawy A, Al-Karmalawy AA. Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments. Biomed Pharmacother. 2023 Dec;168:115734. doi: 10.1016/j.biopha.2023.115734.
  28. A.E.López-Reyes,F.Escobedo-Aguirre,M.P.Lugo-Cruzetal. Efectos perinatales de la metformina en diabetes gestacional. Volume 48, Issue 3, July–September 2021, 100636. https://doi.org/10.1016/j.gine.2020.09.002
  29. Juan J, Yang H. Prevalence, Prevention, and Lifestyle Intervention of Gestational Diabetes Mellitus in China. Int J Environ Res Public Health. 2020 Dec 18;17(24):9517. doi: 10.3390/ijerph17249517.
  30. Boggess KA, Valint A, Refuerzo JS, Zork N, Battarbee AN, Eichelberger K, Ramos GA, Olson G, Durnwald C, Landon MB, Aagaard KM, Wallace K, Scifres C, Rosen T, Mulla W, Valent A, Longo S, Young L, Marquis MA, Thomas S, Britt A, Berry D. Metformin Plus Insulin for Preexisting Diabetes or Gestational Diabetes in Early Pregnancy: The MOMPOD Randomized Clinical Trial. JAMA. 2023 Dec 12;330(22):2182-2190. doi: 10.1001/jama.2023.22949.
  31. Benhalima K, Beunen K, Siegelaar SE, Painter R, Murphy HR, Feig DS, Donovan LE, Polsky S, Buschur E, Levy CJ, Kudva YC, Battelino T, Ringholm L, Mathiesen ER, Mathieu C. Management of type 1 diabetes in pregnancy: update on lifestyle, pharmacological treatment, and novel technologies for achieving glycaemic targets. Lancet Diabetes Endocrinol. 2023 Jul;11(7):490-508. doi: 10.1016/S2213-8587(23)00116-X.
  32. McNestry C, Killeen SL, Crowley RK, McAuliffe FM. Pregnancy complications and later life women's health. Acta Obstet Gynecol Scand. 2023 May;102(5):523-531. doi: 10.1111/aogs.14523.
  33. Guevara-Ramírez P, Paz-Cruz E, Cadena-Ullauri S, Ruiz-Pozo VA, Tamayo-Trujillo R, Felix ML, Simancas-Racines D, Zambrano AK. Molecular pathways and nutrigenomic review of insulin resistance development in gestational diabetes mellitus. Front Nutr. 2023 Sep 20;10:1228703. doi: 10.3389/fnut.2023.1228703.
  34. Rohini HN, Punita P, Santhekadur PK, Ravishankar MV. Gestational Diabetes Mellitus - The Modern Indian Perspective. Indian J Endocrinol Metab. 2023 Sep-Oct;27(5):387-393. doi: 10.4103/ijem.ijem_147_23. Epub 2023 Oct 30.
  35. Rawat D, Chowdhury SR, Yadav AK, Gupta Y, Singh N, Sharma KA, Bharti J, Vatsa R, Zangmo R. Meta-analysis comparing diabetes in pregnancy study group India (DIPSI) vs the international association of the diabetes and pregnancy study groups (IADPSG) criteria for diagnosis of gestational diabetes among Indian population. Taiwan J Obstet Gynecol. 2023 Jul;62(4):498-505. doi: 10.1016/j.tjog.2023.03.013.
  36. American Diabetes Association. 14. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes-2021. Diabetes Care. 2021 Jan;44(Suppl 1):S200-S210. doi: 10.2337/dc21-S014.

Cómo citar

1.
Robles Granda E, Domo Tomalá DS, Chango Ramírez Ángel G, Estrada García LD, Yugcha Andino GE, Calderón León MF. Diabetes gestacional. Una revisión sistemática . Rev. Med. UCSG [Internet]. 20 de febrero de 2025 [citado 23 de febrero de 2025];25(1):13-22. Disponible en: https://editorial.ucsg.edu.ec/ojs-medicina/index.php/ucsg-medicina/article/view/1240

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